About us

A neuroscience-focused biopharmaceutical company dedicated to delivering life-changing therapeutics for people in need

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At Xenon, we are united by a common mission: to deliver innovative medicines that provide a brighter future for people living with neurological and psychiatric disorders. This purpose has driven our scientific curiosity and innovation in ion channel science, and it is enabling us to build a world-class, fully integrated company capable of turning scientific breakthroughs into life-changing medicines. The progress we’ve made since our founding fuels our optimism for the transformative potential of our pipeline to help patients who have been underserved for too long. From our science to our community partnerships, we are committed to making a meaningful impact and reshaping treatment paradigms.”

Ian MortimerPresident and CEO

Meet our team

Our company is guided by a leadership team with decades of combined experience in drug discovery, development, and commercialization. Driven by the pursuit of breakthrough science and patient-centered care, our multidisciplinary team blends scientific excellence with strategic vision.

Ian Mortimer photo

Ian Mortimer

President and Chief Executive Officer
Darren Cline photo

Darren Cline

Chief Commercial Officer
Andrea DiFabio photo

Andrea DiFabio

Chief Legal Officer and Corporate Secretary
James Empfield photo

James Empfield

Executive Vice President, Drug Discovery
Tucker Kelly photo

Tucker Kelly

Chief Financial Officer
Christopher Kenney photo

Christopher Kenney

Chief Medical Officer
Shelley McCloskey photo

Shelley McCloskey

Executive Vice President, Human Resources
Matthew Ronsheim photo

Matthew D. Ronsheim

Chief Operating Officer
Robin Sherrington photo

Robin Sherrington

Executive Vice President, Strategy and Innovation

Our story

Heritage in ion channel science

Xenon was founded in 1996 with a focus on discovering new genetic targets to treat human disease. Soon, we became inspired by the opportunity to translate our genetic insights into life-changing medicines, prompting us to establish our own drug discovery and clinical development capabilities and pursue collaborations with multiple premier biopharmaceutical companies. One of our early areas of focus was the sodium channel Nav1.7, which launched our decades-long scientific commitment to ion channel drug discovery, particularly those expressed in the central and peripheral nervous system.

In 2014, we became a publicly traded company in the US with the intent to become a fully integrated biotechnology company. We started to narrow the focus of our proprietary pipeline to neuroscience, leveraging our heritage in genetics and expertise in ion channel biology.

Today, we have one of the deepest pipelines of ion channel modulators in the industry. With a robust Phase 3 program across epilepsy and depression for our lead candidate, azetukalner, early-stage programs in pain, and a broad pipeline targeting sodium and potassium channels, we are primed to sustainably deliver innovative medicines to people in need.

View some of the milestones from present day to our founding below.
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Today, we are one of the scientific leaders in ion channel drug discovery, with a deep focus on potassium (Kv7) and sodium (Nav) channel modulators to address neurological and psychiatric disorders
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Completed enrollment of the Phase 3 X-TOLE2 study of azetukalner for the treatment of focal seizures
Initiated a Phase 1 clinical trial for XEN1701, Xenon’s lead Nav1.7 development candidate for pain
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Initiated a Phase 3 study of azetukalner for the treatment of bipolar depression, X-CEED
Initiated a Phase 1 clinical trial for XEN1120, a novel Kv7 potassium channel opener in development for pain
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Initiated Phase 3 clinical trials for azetukalner in major depressive disorder, X-NOVA2 and X-NOVA3, based on encouraging results from X-NOVA
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Initiated Phase 3 X-ACKT trial for generalized seizures
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Initiated Phase 3 program for azetukalner in adult patients with focal seizures, consisting of the X-TOLE2 and X-TOLE3 trials
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Conducted Phase 2 clinical trial, X-NOVA, to evaluate azetukalner in patients with major depressive disorder
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Announced positive Phase 2b data for azetukalner in epilepsy and committed to 7-year, open-label extension study

2020s

Established partnership with Neurocrine Biosciences to develop selective sodium channel inhibitors for epilepsy
Initiated clinical development of azetukalner, a novel Kv7 potassium channel opener
Narrowed therapeutic focus to neuroscience, including epilepsy
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Transitioned to public company in the US with goal of building a proprietary pipeline that would result in innovative new medicines
Strategic partnerships with multiple premier biopharmaceutical companies focused on a variety of therapeutic areas, including pain, metabolic, and cardiovascular disease
Established internal discovery and clinical development capabilities to translate genetic insights into novel therapeutic candidates
Foundational discovery work identifying association of the SCN9A gene (loss of function in Nav1.7) with congenital indifference to pain

2000s

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Xenon is founded with platform science capable of discovering new genetic targets to treat human disease

The power behind our progress

Driving innovation forward