About Primary Generalized Tonic Clonic Seizures
Seizures are generally described in two major groups: generalized onset seizures and focal onset seizures. Primary generalized seizures initiate in both hemispheres of the brain simultaneously and are the second most common type of seizure experienced by people with epilepsy. PGTCS, also known as grand mal seizures or convulsions, are severe and life-threatening seizures comprised of tonic and clonic phases. Approximately 30% of patients with epilepsy have generalized seizures, which results in a total adult generalized seizure patient population of approximately 0.9 million patients in the U.S., of which at least 0.7 million patients experience PGTCS. Despite the more severe seizure phenotype, fewer ASMs are currently approved to treat PGTCS compared to FOS and approximately 30% of PGTCS patients are considered inadequately managed with initial lines of therapy warranting additional treatment options.