XEN007, A CaV2.1 Calcium Channel Modulator
XEN007 (active ingredient flunarizine) is a CNS-acting calcium channel modulator that modulates Cav2.1 and T-type calcium channels. Other reported mechanisms include dopamine, histamine and serotonin inhibition. Flunarizine is available in certain countries outside of the United States and has been reported to have clinical benefit in treating migraine and other neurological disorders.
Various development strategies for XEN007 are under consideration. We have entered into key exclusive licensing agreements in order to access regulatory files and drug product manufacturing, both of which may enable advanced clinical development of XEN007. The FDA granted ODD for the treatment of hemiplegic migraine with XEN007, and granted ODD and a rare pediatric disease, or RPD, designation for the treatment of alternating hemiplegia of childhood with XEN007.