Responsibilities:

• Manage Xenon’s drug metabolism and pharmacokinetics function.
• Scientific oversight and management of all ADME/PK studies supporting drug discovery projects across multiple therapeutic areas.
• Manage relationships with CRO’s supporting DMPK activities where applicable.
• Development and maintenance of methodologies, SOP’s and other components of the ADME/PK department's processes.
• Provide regular updates on DMPK activities to senior management.
• Create and maintain a work environment in which scientific challenge and innovation are maximized and communication is open.
• Serve as the DMPK representative on Discovery teams, providing functional area expertise and interacting with scientists across all disciplines in developing and executing development strategies.

Requirements:

• Ph.D. in Pharmaceutical Chemistry, Biochemistry, Pharmacology, Pharmaceutics or a related pharmaceutical science.
• 8+ years of relevant industry experience in applying ADME/PK to the discovery and development of small molecules that have successfully advanced in clinical development.
• Experience in CNS indications preferred but not required.
• Demonstrated knowledge of and experience with mechanistic approaches to understanding the metabolism and pharmacokinetics of novel small molecule therapeutics as applicable to drug discovery and development.
• Experience with regulatory filings is required and with FDA interactions is preferred.
• Excellent communication (written and oral), organization, networking and interpersonal skills are essential.

Please submit your CV and a cover letter to careers@xenon-pharma.com.