EM is a rare autosomal dominant condition characterized by debilitating spontaneous or easily evoked attacks of symmetrical burning pain in the feet and hands, typically associated with elevated skin temperature and erythema (redness of the skin). Symptoms are generally induced by exercise, prolonged standing, exposure to heat, and/or changes in humidity. The pain can be so severe that it can lead to suicide, and adequate treatment remains very challenging.

Orphan Drug Designation is granted by the FDA Office of Orphan Drug Products to novel drugs intended to treat rare disease or condition affecting fewer than 200,000 people in the U.S. This designation confers special incentives to the drug developer, including tax credits towards the cost of clinical trials, prescription drug user fee waivers and may entitle a period of seven years U.S market exclusivity upon FDA approval.

“We are very pleased to receive orphan drug designation for XEN402. Through development of this drug, we hope to address the significant unmet medical need for patients who suffer from chronic pain related to erythromelalgia,” said Dr. Michael Hayden, President of Global R&D and Chief Scientific Officer for Teva Pharmaceutical Industries, Ltd. “XEN402, which inhibits the SCN9A sodium channel, is being developed as a non-opioid approach to pain management.”

“The granting of this orphan-drug designation is another important milestone for our XEN402 development” said Simon Pimstone, President and CEO of Xenon. “Xenon was founded with a commitment to identifying novel targets and from these, novel drugs for difficult to treat rare diseases. We are excited by the promise XEN402 has shown in early proof-of-concept trials and are committed to its development as a novel therapy for the treatment of pain associated with erythromelalgia.”

About XEN402
XEN402 is a novel chemical entity that has been exclusively licensed worldwide to Teva Pharmaceutical Industries Ltd (NYSE: TEVA). XEN402 inhibits the SCN9A sodium channel. Data from a published phase II study, suggest that XEN402 may relieve the pain associated with erythromelalgia (Pain 2012 Jan; 153(1):80-5).

About Teva
Teva Pharmaceutical Industries Ltd. (NYSE: TEVA) is a leading global pharmaceutical company, committed to increasing access to high-quality healthcare by developing, producing and marketing affordable generic drugs as well as innovative and specialty pharmaceuticals and active pharmaceutical ingredients. Headquartered in Israel, Teva is the world’s leading generic drug maker, with a global product portfolio of more than 1,000 molecules and a direct presence in about 60 countries. Teva’s branded businesses focus on CNS, oncology, pain, respiratory and women’s health therapeutic areas as well as biologics. Teva currently employs approximately 46,000 people around the world and reached $20.3 billion in net revenues in 2012.

About Xenon Pharmaceuticals Inc. (Xenon)
Xenon is a privately owned, rare disease company developing innovative medicines based on our genetically validated drug targets. For more information, visit the Company’s website at http://www.xenon-pharma.com.

Teva’s Safe Harbor Statement under the U. S. Private Securities Litigation Reform Act of 1995:
This release contains forward-looking statements, which express the current beliefs and expectations of management. Such statements are based on management’s current beliefs and expectations and involve a number of known and unknown risks and uncertainties that could cause our future results, performance or achievements to differ significantly from the results, performance or achievements expressed or implied by such forward-looking statements. Important factors that could cause or contribute to such differences include risks relating to: our ability to develop and commercialize additional pharmaceutical products, competition for our innovative products, especially Copaxone® (including competition from innovative orally-administered alternatives, as well as from potential purported generic equivalents), competition for our generic products (including from other pharmaceutical companies and as a result of increased governmental pricing pressures), competition for our specialty pharmaceutical businesses, our ability to achieve expected results through our innovative R&D efforts, the effectiveness of our patents and other protections for innovative products, decreasing opportunities to obtain U.S. market exclusivity for significant new generic products, our ability to identify, consummate and successfully integrate acquisitions, the effects of increased leverage as a result of recent acquisitions, the extent to which any manufacturing or quality control problems damage our reputation for high quality production and require costly remediation, our potential exposure to product liability claims to the extent not covered by insurance, increased government scrutiny in both the U.S. and Europe of our agreements with brand companies, potential liability for sales of generic products prior to a final resolution of outstanding patent litigation, including that relating to the generic version of Protonix®, our exposure to currency fluctuations and restrictions as well as credit risks, the effects of reforms in healthcare regulation and pharmaceutical pricing and reimbursement, any failures to comply with complex Medicare and Medicaid reporting and payment obligations, governmental investigations into sales and marketing practices (particularly for our specialty pharmaceutical products), uncertainties surrounding the legislative and regulatory pathways for the registration and approval of biotechnology-based products, adverse effects of political or economical instability, corruption, major hostilities or acts of terrorism on our significant worldwide operations, interruptions in our supply chain or problems with our information technology systems that adversely affect our complex manufacturing processes, any failure to retain key personnel or to attract additional executive and managerial talent, the impact of continuing consolidation of our distributors and customers, variations in patent laws that may adversely affect our ability to manufacture our products in the most efficient manner, potentially significant impairments of intangible assets and goodwill, potential increases in tax liabilities, the termination or expiration of governmental programs or tax benefits, environmental risks and other factors that are discussed in our Annual Report on Form 20-F for the year ended December 31, 2012 and in our other filings with the U.S. Securities and Exchange Commission. Forward-looking statements speak only as of the date on which they are made and the Company undertakes no obligation to update or revise any forward-looking statement, whether as a result of new information, future events or otherwise.

Xenon Safe Harbor
This release contains forward-looking statements that are not based on historical fact. These forward-looking statements involve risks, uncertainties and other factors that may cause the actual results, events or developments to be materially different from those expressed or implied by such forward-looking statements. Readers are cautioned not to place undue reliance on such forward-looking statements.

Contact Information

The prestigious Gold Leaf Awards ceremony will take place on Tuesday, April 23 at the BIO International Convention in Chicago. Several thousand guests will be in attendance, representing the global life sciences community.

“We are honored to be recognized by our national industry peers in this way,” commented Simon Pimstone, Xenon’s President and CEO. “The team at Xenon has worked hard to create an exciting pipeline of products and have executed on multiple partnerships with leading industry partners. One of Xenon’s early discoveries forms the active ingredient of the gene therapy product Glybera®, which has recently been approved in Europe to treat lipoprotein lipase deficiency. Xenon’s XEN402 analgesic product, which is partnered with Teva, will soon be entering phase 2b trials. This year, we also expect to file an investigational new drug (IND) application on our XEN701 antisense product for the treatment of anemia in renal disease patients who are erythropoietin (EPO) resistant or EPO intolerant. 2013 promises to be a very exciting year for Xenon as we continue to advance our products for rare diseases.”

About Xenon Pharmaceuticals Inc.
Xenon is a privately owned, clinical genetics-based drug discovery and development company engaged in developing novel therapies for rare diseases. For more information, visit the Company’s website at http://www.xenon-pharma.com.

For more information regarding this press release, contact: Dr. Robin Sherrington, SVP Business & Corporate Development (604) 484-3300, ddunn@xenon-pharma.com

This release contains forward-looking statements that are not based on historical fact. These forward-looking statements involve risks, uncertainties and other factors that may cause the actual results, events or developments to be materially different from those expressed or implied by such forward-looking statements. Readers are cautioned not to place undue reliance on such forward-looking statements.

“We are very pleased that Merck has exercised this option to license novel discoveries from the collaboration,” said Simon Pimstone, President and CEO of Xenon. “The discovery of loss-of-function mutations for this target in humans with protective cardiovascular profiles was central for the development of compound modulators of the target.”

Under the terms of the 2009 agreement, Xenon received milestone payments and an option fee and is eligible for further research, development and regulatory milestone payments of up to US$86.5 million. In addition, Merck will pay Xenon undisclosed royalties on sales of products resulting from the collaboration.

About Xenon Pharmaceuticals Inc. (Xenon)
Xenon is a privately owned, clinical genetics-based drug discovery and development company engaged in developing novel therapies for rare diseases. For more information, visit the Company’s website at http://www.xenon-pharma.com.

For more information regarding this press release, contact:
Dr. Robin Sherrington, SVP Business & Corporate Development (604) 484-3363, ddunn@xenon-pharma.com.

This release contains forward-looking statements that are not based on historical fact. These forward-looking statements involve risks, uncertainties and other factors that may cause the actual results, events or developments to be materially different from those expressed or implied by such forward-looking statements. Readers are cautioned not to place undue reliance on such forward-looking statements.

ACCOUNTABILITIES & RESPONSIBILITIES:

Day-to-day administrative support including:
• Answering, screening and directing phone calls.
• Supporting other team members as required by the VP, Clinical or Executive VP, R&D.
• Interacting with Xenon collaborators/partners by telephone and e-mail.
• Preparing, typing, compiling, transmitting and filing of correspondence, memos, reports, proposals, minutes of meetings, presentations, graphics, slides, briefing documents, etc.
• Taking dictation and/or transcribing from Dictaphone.
• Organizing and scheduling internal and external teleconferences, videoconferences and meetings including contacting participants, booking rooms, ordering/purchasing food and refreshments, and cleaning up meeting rooms afterward as required.
• Arranging for catering for meetings as required.
• Maintaining address books in GroupWise and Rolodexes.
• Maintaining and organizing of department records and files.
• Making travel arrangements directly with the airlines, hotels, car rental companies, et cetera, by phone or using their web sites for North American and straightforward travel, and using a travel agent for more complicated and overseas travel. Preparing detailed travel packages, including itineraries and supporting documents.
• Preparing expense account claims. Reconciling credit card statements to receipts as per expenditure account guidelines.
• Assisting in planning corporate events.
• Providing occasional reception relief as required.
• Assisting other Executive Assistant in daily kitchen duty, including running and emptying dishwashers.

KNOWLEDGE & EDUCATION REQUIREMENTS:

• 5 years recent experience as an Executive Assistant.
• Proficient computer skills and in-depth knowledge of relevant software, including MS Word, Excel, Power Point .
• Proficient in using an e-mail program, preferably Groupwise.
• Skilled at using the Internet to book travel, locate contact details, create maps, et cetera.
• Excellent prioritizing, organizing, planning and decision-making skills.
• Excellent interpersonal, oral and written communication skills.
• A self-starter who shows initiative and works well as a team member.
• Flexible and adaptable.
• Accurate and detail-oriented.
• High standard of ethics, confidentiality and diplomacy in the handling of sensitive information.
• Skilled at multitasking in a fast-paced environment.

To apply for this position, please e-mail resumes to careers@xenon-pharma.com. Please include “Executive Assistant” in the subject line. We thank all applicants for their interest; however, due to the volume of applicants, only those chosen for interview will be contacted.

ACCOUNTABILITIES & DELIVERABLES:

1. Patient Collection

Responsible for contacting physicians, patients and families, and coordinating the recruitment of family participants.

2. Clinical Project Coordination

Responsible for coordinating all incoming information of collection phase of project. This includes, but is not limited to:

• Ensuring appropriate ethical approval, protocols, and consent is in place
• Maintaining and updating pedigrees
• Coordinating appropriate shipment of samples
• Coordinating appropriate arrival, storage and assessment of all clinical data
• Creating and communicating project status updates

3. Literature Reviews and Analyses

Responsible for reviewing the literature on disease areas relevant to the Company, including:

• Collating and analyzing the literature
• Maintaining up-to-date information on pertinent literature
• Literature review and analyses of new emerging areas of interest to the Company

4. Communication

Responsible for communicating diagnostic findings where appropriate to physicians and patients.

KNOWLEDGE & EDUCATION REQUIREMENTS:

• Masters Degree in Genetic Counselling preferred (similar education and experience will be considered)
• Certification / eligibility for certification from CCGC / ABGC preferred
• Experience in research genetics important with knowledge of study protocols and ethical review process
• Knowledge of human sample collection, pedigree drawing and phenotype analysis
• Knowledge of molecular genetics and an understanding for genotyping and sequencing techniques
• Experience in project management (contracts, budgets, timelines) an asset
• Strong medical writing skills
• Experience in biotechnology or pharmaceutical industry an asset but not required
• Excellent communication and organizational skills
• Must be able to multi-task, meet deadlines, communicate and disseminate pertinent information effectively
• Must work well independently and as part of a larger team
• Must be available to travel as required (<5% of job)

To apply for this position, please e-mail resumes to careers@xenon-pharma.com. Please include “Genetics Counsellor” in the subject line. We thank all applicants for their interest; however, due to the volume of applicants, only those chosen for interview will be contacted.

The LifeSciences British Columbia Awards took place on Thursday, April 4 at the Vancouver Convention Centre with several hundred guests representing the British Columbia life sciences community.

“We are honored to be recognized by our industry peers in this way” commented Simon Pimstone, Xenon’s President and CEO. “This is the beginning of a very exciting year for Xenon. We’ve worked diligently and deliberately to create strong partnerships with top tier pharmaceutical companies and to develop a deep and diverse pipeline of products. One of Xenon’s early technologies is now in an approved product to treat lipoprotein lipase deficiency, we have a late stage clinical program initiating for our novel pain medicine and an early development stage product for the treatment of anemia. We look forward to an exciting year at Xenon as our products advance on the market and in the clinic”

About Xenon Pharmaceuticals Inc.
Xenon is a privately owned, clinical genetics-based drug discovery and development company engaged in developing novel therapies for rare diseases. For more information, visit the Company’s website at http://www.xenon-pharma.com.

For more information regarding this press release, contact: Dr. Robin Sherrington, SVP Business & Corporate Development (604) 484-3300, ddunn@xenon-pharma.com

This release contains forward-looking statements that are not based on historical fact. These forward-looking statements involve risks, uncertainties and other factors that may cause the actual results, events or developments to be materially different from those expressed or implied by such forward-looking statements. Readers are cautioned not to place undue reliance on such forward-looking statements.

“We are delighted to welcome Gary to the Xenon team” commented Simon Pimstone, Xenon’s President and CEO. “As a co-founder and CSO of AnorMED, he was responsible for the development of MOZOBIL, a hematopoietic stem cell mobilizing agent for non-Hodgkin’s lymphoma and multiple myeloma patients, from discovery through completion of phase III trials. Having also held an executive position at Genzyme, Gary will bring a unique experience to Xenon of small and large public biotech and orphan drug development. I am confident that Gary will make many major contributions to Xenon’s future growth.”

Dr. Bridger has spent over 20 years in the life sciences industry including positions at Johnson Matthey, AnorMED and Genzyme. Dr. Bridger was a primary member of the team that managed AnorMED’s acquisition by Genzyme for US$580 million. Prior to joining Xenon he was a partner with Ventures West Capital Management and he currently serves on the Scientific Advisory Board of Alectos Pharmaceuticals. Dr. Bridger received his PhD in Organic Chemistry from the University of Manchester UK and completed a post-doctoral fellowship at Boston College. He is the co-author of more than 90 peer-reviewed publications and 40 granted US patents, mainly in the field of chemokine receptor antagonists.

About Xenon Pharmaceuticals Inc. (Xenon)
Xenon is a privately owned, clinical genetics-based drug discovery and development company engaged in developing novel therapies for rare diseases. For more information, visit the Company’s website at http://www.xenon-pharma.com.

For more information regarding this press release, contact: Dr. Simon Pimstone, President & CEO, (604) 484-3300, ddunn@xenon-pharma.com

This release contains forward-looking statements that are not based on historical fact. These forward-looking statements involve risks, uncertainties and other factors that may cause the actual results, events or developments to be materially different from those expressed or implied by such forward-looking statements. Readers are cautioned not to place undue reliance on such forward-looking statements.

Xenon exclusively licensed to uniQure BV its rights to the LPL^S447X genetic variant that causes a gain of function in the lipoprotein lipase (LPL) gene in humans. Humans with the LPL^S447X variant have been shown on average to have lower triglyceride and higher HDL cholesterol levels than those without LPL^S447X. Glybera developed by uniQure is an adeno-associated virus based human gene therapy that contains LPL^S447X and in clinical studies Glybera was effective in reducing blood fat levels and episodes of pancreatitis in patients with LPLD.

“The approval of Glybera is an important milestone for our Company and for the gene therapy field in general,” said Simon Pimstone, President and CEO of Xenon. “Xenon was founded with a commitment to advancing human genetic discoveries into novel therapies for difficult to treat orphan diseases and Glybera is the first product to be marketed by one of our licensees.”

In addition to the milestone payment Xenon is also entitled to receive from uniQure BV royalty payments on sales of Glybera, which is expected to start selling in Europe in 2013. The LPL^S447X technology in Glybera was conceived and developed by Xenon’s former CSO Michael Hayden at the Center of Molecular Medicine, University of British Columbia.

About Xenon Pharmaceuticals Inc. (Xenon)
Xenon is a privately owned, clinical genetics-based drug discovery and development company engaged in developing novel therapies for rare diseases. For more information, visit the Company’s website at http://www.xenon-pharma.com.

For more information regarding this press release, contact:
Dr. Robin Sherrington, SVP, Business & Corporate Development
(604) 484-3363, rsherrington at xenon-pharma.com.

This release contains forward-looking statements that are not based on historical fact. These forward-looking statements involve risks, uncertainties and other factors that may cause the actual results, events or developments to be materially different from those expressed or implied by such forward-looking statements. Readers are cautioned not to place undue reliance on such forward-looking statements.

Jerusalem, and Burnaby, British Columbia (December 11, 2012) — Teva Pharmaceutical Industries Ltd (NYSE: TEVA) and Xenon Pharmaceuticals Inc. (Xenon) announced today that they have entered into a collaborative development and exclusive worldwide license for XEN402. XEN402 is currently in clinical development for a variety of painful disorders. This product specifically targets sodium channels which are abundantly found in sensory nerve endings that can increase in chronic painful conditions. Under the Agreement, Teva will pay Xenon an upfront fee of $41 million. In addition Teva shall pay development, regulatory, and sales-based milestones totaling up to $335M. Xenon is entitled to royalties payable on sales and an option to participate in commercialization in the U.S.

“Teva is building a focused pipeline of novel medicines in select areas of medical need,” stated Dr. Jeremy Levin, President and CEO of Teva Pharmaceutical Industries Ltd. “XEN402 fits this strategy. It holds the potential to address the significant unmet medical need for the many patients who suffer from chronic pain. In addition, XEN402 has the potential for broader therapeutic use across other pain conditions.”

“We are delighted to be collaborating with Teva,” said Simon Pimstone, M.D., Ph.D., President and CEO of Xenon. “Teva is among the world’s leading pharmaceutical companies and is building a significant global presence in innovative drug development and commercialization. This partnership with Teva is Xenon’s seventh major pharmaceutical alliance, once again highlighting the value of Xenon’s unique genetics approach and translational R&D capabilities.”

About XEN402
XEN402 treats pain locally at its source through blocking of Nav1.7 and Nav1.8 sodium channels. XEN402 has been studied in human subjects as both oral and topical forms. In a published study, oral XEN402 was shown to be effective at relieving the pain associated with the rare neuropathic pain condition, erythromelalgia (Pain 2012 Jan;153(1):80-5). Topical XEN402 was studied in a phase 2 trial to evaluate for effectiveness in alleviating the pain of post herpetic neuralgia. In this study the proportion of patients reporting clinically meaningful reductions in pain was significantly greater for topical XEN402 than for placebo (p=0.049 for >30% response and p=0.0078 for >50% response).

About Teva
Teva Pharmaceutical Industries Ltd. (NYSE: TEVA) is a leading global pharmaceutical company, committed to increasing access to high-quality healthcare by developing, producing and marketing affordable generic drugs as well as specialty pharmaceuticals and active pharmaceutical ingredients. Headquartered in Israel, Teva is a world leading generic drug maker, with a global product portfolio of more than 1,300 molecules and a direct presence in about 60 countries. Teva’s branded businesses focus on CNS, oncology, pain, respiratory and women’s health therapeutic areas. Teva currently employs approximately 46,000 people around the world and reached $18.3 billion in net revenues in 2011.

About Xenon Pharmaceuticals Inc. (Xenon)
Xenon is a privately owned, clinical genetics-based drug discovery and development company engaged in developing novel therapies based on the genetic causes of select metabolic, neurological and cardiovascular diseases. For more information, visit the Company’s website at http://www.xenon-pharma.com. Dr. Michael Hayden, Teva’s President of Global R&D and Chief Scientific Officer, is a director and founder of Xenon.

Teva Safe Harbor
The following discussion and analysis contains forward-looking statements, which express the current beliefs and expectations of management. Such statements involve a number of known and unknown risks and uncertainties that could cause our future results, performance or achievements to differ significantly from the results, performance or achievements expressed or implied by such forward-looking statements. Important factors that could cause or contribute to such differences include risks relating to: our ability to develop and commercialize additional pharmaceutical products, competition from the introduction of competing generic equivalents and due to increased governmental pricing pressures, the effects of competition on sales of our innovative medicines, especially Copaxone® (including competition from innovative orally-administered alternatives as well as from potential generic equivalents), potential liability for sales of generic medicines prior to a final resolution of outstanding patent litigation, including that relating to our generic version of Protonix®, the extent to which we may obtain U.S. market exclusivity for certain of our new generic medicines, the extent to which any manufacturing or quality control problems damage our reputation for high quality production and require costly remediation, our ability to identify, consummate and successfully integrate acquisitions (including the acquisition of Cephalon), our ability to achieve expected results through our innovative R&D efforts, dependence on the effectiveness of our patents and other protections for innovative medicines, intense competition in our specialty pharmaceutical businesses, uncertainties surrounding the legislative and regulatory pathway for the registration and approval of biotechnology-based medicines, our potential exposure to product liability claims to the extent not covered by insurance, any failures to comply with the complex Medicare and Medicaid reporting and payment obligations, our exposure to currency fluctuations and restrictions as well as credit risks, the effects of reforms in healthcare regulation and pharmaceutical pricing and reimbursement, adverse effects of political instability and adverse economic conditions, major hostilities or acts of terrorism on our significant worldwide operations, increased government scrutiny in both the U.S. and Europe of our agreements with brand companies, interruptions in our supply chain or problems with our information technology systems that adversely affect our complex manufacturing processes, the impact of continuing consolidation of our distributors and customers, the difficulty of complying with U.S. Food and Drug Administration, European Medicines Agency and other regulatory authority requirements, potentially significant impairments of intangible assets and goodwill, potential increases in tax liabilities resulting from challenges to our intercompany arrangements, the termination or expiration of governmental programs or tax benefits, any failure to retain key personnel or to attract additional executive and managerial talent, environmental risks, and other factors that are discussed in our Annual Report on Form 20-F for the year ended December 31, 2011 and in our other filings with the U.S. Securities and Exchange Commission (“SEC”). Forward-looking statements speak only as of the date on which they are made, and we undertake no obligation to update any forward-looking statements or other information contained in this report, whether as a result of new information, future events or otherwise.

Xenon Safe Harbor
This release contains forward-looking statements that are not based on historical fact. These forward-looking statements involve risks, uncertainties and other factors that may cause the actual results, events or developments to be materially different from those expressed or implied by such forward-looking statements. Readers are cautioned not to place undue reliance on such forward-looking statements.

Contact Information

“We are delighted to be collaborating with Genentech” said Simon Pimstone, President and CEO of Xenon. “Genentech is among the world’s leading biotech companies and an ideal strategic partner for Xenon as we share a common emphasis on using human genetics for drug development. Further, this collaboration allows Xenon to both deepen and broaden our pipeline of novel medicines in development.”

Xenon and Genentech will collaborate on the discovery of new therapeutic approaches for treating pain. Under the terms of the agreement, Genentech has an exclusive license to compounds and a non-exclusive license to diagnostics from Xenon for development and commercialization of products. Xenon will receive an undisclosed upfront payment, research funding and is eligible to receive research, development and commercialization milestone payments, totaling up to $646 million for multiple products and indications. In addition, Xenon will receive royalties on sales of products resulting from the collaboration.

Michael Hayden, CSO of Xenon added: “This new alliance, which represents our sixth partnership with a major pharmaceutical company to date, once again highlights the keen interest in Xenon’s unique genetics approach and in our translational R&D capabilities.”

About Xenon Pharmaceuticals Inc. (Xenon)
Xenon is a privately owned, clinical genetics-based drug discovery and development company engaged in developing small molecule therapies based on the genetic causes of select metabolic, neurological and cardiovascular diseases. For more information, visit the Company’s website at http://www.xenon-pharma.com.

For more information regarding this press release, contact:
Dr. Robin Sherrington, VP, Business & Corporate Development (604) 484-3363 ddunn@xenon-pharma.com

This release contains forward-looking statements that are not based on historical fact. These forward-looking statements involve risks, uncertainties and other factors that may cause the actual results, events or developments to be materially different from those expressed or implied by such forward-looking statements. Readers are cautioned not to place undue reliance on such forward-looking statements.